Health Condition 1: F321- Major depressive disorder, singleepisode, moderate
Conditions
Interventions
None listed
Sponsors
YANTRA Project, Ministry of Ayush, Govt. of India
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients between age group of 18 to 50 years 2.Meets DSM5 criteria for single or recurrent nonpsychotic MDD 3. Hamilton Depression Rating Scale HAMD greater than 7 to less than 17. 4. Capacity to consent will be evaluated using UBACC scale.
Exclusion criteria
Exclusion criteria: .Suicidal ideation with intent in the prior year according to CSSRS (Gipson et al., 2015) 2.Already on any medication for depression. 3.History of bipolar disorder, schizophrenia, schizoaffective disorder, substance abuse or dependence (except tobacco), OCD or any other axis-1 psychiatric disorder 4.Any major neurological disorder and other severe medical comorbidities 5.Pregnancy or lactation 6. Use of probiotics, antibiotics, immunomodulators, or gastrointestinal (GI) medicines in the last three one month. 7. Patient diagnosed with of GI disorders, endocrine disorders, or immunological conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma Short-Chain Fatty Acids, MicroRNA (miR-16, miR-135a, miR-1202), and cortical excitability parameters (SICI, LICI & ICF, SP)Timepoint: Baseline (0th Day ) and 8th Week of Intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| including Tumor Necrosis Factor-alpha, interleukins (IL-6), CRP,BDNFTimepoint: Baseline (0th Day ) and 8th Week of Intervention | — |
Countries
India
Contacts
Public ContactDr Shivakumar V
National Institute of Mental Health and Neurosciences
Outcome results
None listed