When patients undergo surgery, inserting a breathing tube (endotracheal intubation) can cause a stress response, leading to increased heart rate and blood pressure. Two medications, dexmedetomidine and magnesium sulphate, can help reduce this stress response.

Comparison of efficacy of intravenous Dexmedetomidine versus Magnesium sulphate in Attenuation of hemodynamic response to Larygoscopy and endotracheal intubation in laparoscopic surgery - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/087085

Enrollment

Registered

2025-05-19

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group D - Inj Dexmedetomidine: Group D 1mcg/kg IV dexmedetomidine diluted in 50- ml normal saline over 10 min before induction. Total duration 12 hours Control Intervention1: Group M

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of either sex scheduled to undergo elective surgical laparoscopic procedures under general anesthesia with endotracheal intubation. 2. Patients of ASA grade 1 and II. 3. Patient willing to give the consent.

Exclusion criteria

Exclusion criteria: 1. Patients with history of known allergy to study drugs. 2. History of consumption of antihypertensive drugs, sedatives, Hypnotics and antidepressants preoperatively. 3. Pre-existing cardiovascular disease, significant respiratory, renal and hepatic disorder. 4. History of drugs or alcohol abuse. 5. Pregnant and lactating patients 6. Patients requiring rapid sequence induction of anaesthesia 7. Anticipated difficult bag mask ventilation or oral endotracheal intubation. 8.Unanticipated difficult intubation requiring more than one attempt or equal to more than 30 seconds for successful intubation.

Design outcomes

Primary

Measure	Time frame
To determine the changes in hemodynamic parameters i.o. heart rate, SBP, DBP, MAP and SPO2 from baseline to different time interval after Laryngoscopy and Endotracheal Intubation in the two groups At Baseline,At 10 min before induction,1 min,3 min,5 min,10,20,30 ,50 min then at the end of surgery ,then upto 12 hr post op.Timepoint: To determine the changes in hemodynamic parameters i.o. heart rate, SBP, DBP, MAP and SPO2 from baseline to different time interval after Laryngoscopy and Endotracheal Intubation in the two groups At Baseline,At 10 min before induction,1 min,3 min,5 min,10,20,30 ,50 min then at the end of surgery ,then upto 12 hr post op.	—

Measure

Time frame

To determine the changes in hemodynamic parameters i.o. heart rate, SBP, DBP, MAP and SPO2 from baseline to different time interval after Laryngoscopy and Endotracheal Intubation in the two groups At Baseline,At 10 min before induction,1 min,3 min,5 min,10,20,30 ,50 min then at the end of surgery ,then upto 12 hr post op.Timepoint: To determine the changes in hemodynamic parameters i.o. heart rate, SBP, DBP, MAP and SPO2 from baseline to different time interval after Laryngoscopy and Endotracheal Intubation in the two groups At Baseline,At 10 min before induction,1 min,3 min,5 min,10,20,30 ,50 min then at the end of surgery ,then upto 12 hr post op.

—

Secondary

Measure	Time frame
To assess & compare proportion of patients developing postoperative sedation by Ramsay sedation score &any side effects. Timepoint: At Baseline,At 10 min before induction,1 min,3 min,5 min,10,20,30 ,50 min then at the end of surgery ,then upto 12 hr post op.	—

Countries

India

Contacts

Public ContactDr Veena patodi

Jawahar Lal Nehru medical college

veenapatodi@gmail.com9414008276

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026