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Study Comparing Pain Control from Buprenorphine Patch and Tramadol Injection After Open Abdominal Surgery

A comparative study between transdermal Buprenorphine patch with intravenous Tramadol for postoperative analgesia in patients undergoing Laparotomy surgeries under general anaesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087049
Enrollment
60
Registered
2025-05-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K529- Noninfective gastroenteritis and colitis, unspecified

Interventions

Intervention1: Transdermal Buprenorphine patch 10 mcg/hr : Transdermal Buprenorphine patch 10 mcg/hr is applied 6 hours before the patients undergoing open laparotomy surgeries under general anaesthes

Sponsors

Mahadevappa Rampurae Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing Laparotomy surgeries under general anaesthesia 2. American Society of Anaesthesiologists(ASA) grade : 1 and 2 3. Age 18 to 80 years of either sex weighing between 40kg to 80 kg

Exclusion criteria

Exclusion criteria: 1. History of allergic reactions to the trial drugs 2. Severe hepatic or renal dysfunction 3. BMI is greater than 35 4. Pregnant and lactating women 5. Patients with bleeding disorders, respiratory diseases like chronic obstructive disease, bronchial asthma

Design outcomes

Primary

MeasureTime frame
Out of 30 patients in the Buprenorphine patch group, 18 patients had PONV, 13 patients had itching, and 12 patients had respiratory distress. Out of 30 patients of Intravenous Tramadol group, 12 patients had PONV, 11 patients had itching, 13 patients had respiratory distressTimepoint: Out of 30 patients in the Buprenorphine patch group, 18 patients had PONV, 13 patients had itching, and 12 patients had respiratory distress. Out of 30 patients of Intravenous Tramadol group, 12 patients had PONV, 11 patients had itching, 13 patients had respiratory distress—

Secondary

MeasureTime frame
Time of rescue analgesia is mostly 6-24 hours in the buprenorphine group, while 4 hours in tramadol groupTimepoint: Time of rescue analgesia is mostly 6-24 hours in the buprenorphine group, while 4 hours in tramadol group—

Countries

India

Contacts

Public ContactDr Pavan Kumar Pulyapudi

Mahadevappa Rampurae Medical College

drgurupatil@gmail.com9481002895

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026