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Study to find out whether patients with initial stage of mouth cancer do better if they undergo surgery followed by radiation compared to just undergoing surgery alone.

Ascertaining the impact of adjuvant radiotherapy in early stage risk factor positive oral cavity squamous cell carcinoma and evaluating patterns of failure A project of the Young Investigators Committee under the auspices of the Head and Neck Inter Group - PORTHES-OC

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/05/087040
Enrollment
1500
Registered
2025-05-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D- Radiation Therapy

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

University of Oklahoma
Lead Sponsor
Princess Alexandra Hospital
Collaborator
Tata Memorial Hospital
Collaborator
University of Florence
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Treated for early-stage (cT1-2N0M0) oral cavity cancer They must have been treated with curative intent via surgery, with or without adjuvant therapies Must have had at least two years of follow-up, or death

Exclusion criteria

Exclusion criteria: Patients who are being treated for recurrence (either palliatively or by salvage surgery) or for distant metastasis at presentation

Design outcomes

Primary

MeasureTime frame
Overall Survival between radiation and no radiation groups. Overall Survival between radiation and no radiation groups in patients with WPOI V Timepoint: 3 year, 5 year—

Secondary

MeasureTime frame
Recurrence rates between radiation & no radiation groups. Patterns of recurrence Timepoint: At 2 years—

Countries

Australia, India, Italy, United States of America

Contacts

Public ContactDr Monali Swain

Tata Memorial Hospital

drmonaliswain@gmail.com9920739863

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026