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How Smoking Affects Salivary Markers in Gum Disease A Clinical Study on ICTP and IL 17 Levels

Evaluation of the impact of the salivary level of ICTP and IL17 in periodontitis patients with and without smoking a randomised control clinical trial - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/087013
Enrollment
60
Registered
2025-05-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R888- Abnormal findings in other body fluids and substances

Interventions

Intervention1: control group with healthy subjects: Subjects without any evidence of periodontal and systemic disease. Healthy control group where no sites with 3 mm probing pocket depth (PPD) and att

Sponsors

Neha Sahu
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Outpatients at the hospital within the age group of 18-60 years. 2.Person who are systemically healthy. 3.No history of anti-microbial therapy for the past three months. 4.Able to provide written informed consent and understand the study protocol

Exclusion criteria

Exclusion criteria: 1.Pregnant ladies and Lactating Mothers. 2.Patient with Smokeless tobacco habit. 3.Patients with history of systemic disease. Any underlying systemic disease will have effect on periodontal status. 4.Patients who have undergone periodontal therapy or antibiotic therapy in the past 6 months or any other drugs as there will be effect on the periodontal status. 5.Presence of any pre-existing oral infected condition. For e.g. pulpal pathosis. 6.Any patient undergoing radiation therapy. 7.History of any form of periodontal treatment in the past 3 months.

Design outcomes

Primary

MeasureTime frame
There will be decrease in salivary IL-17 levels & ICTP levels in periodontitis patients & periodontitis patient having smoking habit after nonsurgical periodontal treatment.Timepoint: 1 year 6 month

Secondary

MeasureTime frame
Non-surgical periodontal treatment will have significant impact on bone resorption marker i.e IL-17 level & ICTP levels and will be well correlated with clinical parameters of periodontal tissue destruction.Timepoint: 1 year 6 month

Countries

India

Contacts

Public ContactNeha Sahu

Department of periodontology and implantology, Government Dental College and Hospital, Raipur

Jyotiwasti@YAHOO.IN9826322475

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026