A randomized controlled clinical trial comparing the efficacy of a locally delivered novel probiotic gel with 1 percent chlorhexidine gel in the non-surgical periodontal treatment of patients with stage II periodontitis

Comparative clinical evaluation of locally delivered ingenious probiotic gel with 1 percent chlorhexidine gel in the nonsurgical periodontal treatment of stage II periodontitis patients A randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086986

Enrollment

Registered

2025-05-15

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Group A: Probiotic gel group: Probiotic gel is to be administered in this group of patients after non surgical periodontal therapy. Control Intervention1: Group B: Chlorhexidine gel gro

Eligibility

Inclusion criteria

Inclusion criteria: a. Patients within age group of 18 â?? 45 years. b. Stage II periodontitis patients with at least two non-adjacent teeth with probing depth 3 to 4 mm

Exclusion criteria

Exclusion criteria: a. Patients with chronic diseases such as Diabetes mellitus, arthritis, thyroid disorder, etc. b. Patients using protective or orthodontic appliances. c. Patients who are smokers or using any other tobacco products. d. Female patients who are pregnant and lactating. e. Patient allergic to probiotics

Design outcomes

Primary

Measure	Time frame
The expected outcome is reduction in gingival inflammation, Pocket probing depth, gingival bleeding and increase in clinical attachment level.Timepoint: At baseline, 4 weeks and 12 weeks	—

Secondary

Measure	Time frame
In-vitro outcome is expected to be zone of inhibition to be seen on nutrient agar plate with probiotic gel against aerobic and anaerobic bacteria collected from plaque samples from stage II periodontitis patientsTimepoint: zone of inhibition to be recorded in 24 hours after smearing the plaque samples and probiotic gel on nutrient agar plate	—

Countries

India

Contacts

Public ContactDarshana Borawake

MGVS KBH Dental college and Hospital, Panchavati, Nashik

kunalks2001@yahoo.com98230-20048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026