Health Condition 1: O- Medical and Surgical Health Condition 2: K689- Other disorders of retroperitoneum
Conditions
Interventions
Intervention1: Ropivacaine with Dexmedetomidine: the intervention involves the administration of a quadratus lumborum block (QLB) using a combination of ropivacaine and dexmedetomidine for postoperati
Sponsors
Dr Anajana AJ
Eligibility
Inclusion criteria
Inclusion criteria: The inclusion criteria for this study comprised adult patients aged between 18 and 65 years, of either gender, who were scheduled to undergo abdominal surgery under spinal anesthesia. Eligible participants were those classified as American Society of Anesthesiologists (ASA) physical status I or II, indicating a relatively low operative risk. Additionally, only patients with a body mass index (BMI) ranging from 20 to 30 kg/m were considered for inclusion. Another prerequisite was that the anticipated duration of surgery should be less than three hours to maintain uniformity in operative conditions and postoperative analgesic requirements.
Exclusion criteria
Exclusion criteria: The exclusion criteria for this study included patients who refused to participate or provide informed consent. Individuals with a history of significant systemic illnesses such as cardiac, respiratory, renal, or hepatic failure were excluded to avoid potential confounding effects on postoperative outcomes. Patients with coagulation disorders or local infections at the site of the quadratus lumborum block were also excluded due to increased risk of complications. Additionally, those with psychological disorders, known allergies to the study medications (ropivacaine or dexmedetomidine), or chronic use of pain medications or adrenergic receptor agonists/antagonists were not included. This ensured a homogenous study population and minimized the influence of external variables on analgesic efficacy and safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is to assess and compare the total amount of rescue analgesia required within the first 24 hours following abdominal surgery between the two study groups. This outcome provides a direct measure of the effectiveness of dexmedetomidine as an adjuvant to ropivacaine in prolonging postoperative analgesia and reducing the need for additional pain medication.Timepoint: Within the first 24 hours of the postoperative period. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes are time to first rescue analgesia, postoperative Visual Analogue Scale (VAS) scores, Ramsay Sedation Scores (RSS), and total analgesic requirement in the postoperative period.Timepoint: VAS and RSS scores are recorded at 0, 1, 2, 4, 6, 8, 12, 16, 20, and 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactReetu Verma
King Georges Medical University
Outcome results
None listed