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Study on the Relationship Between Optic Nerve Sheath Diameter (ONSD) and Brain Pressure Measurement in Acute Liver Failure Patients

CO-RELATION BETWEEN OPTIC NERVE SHEATH DIAMETER (ONSD) THROUGH AN ULTRASONOGRAM Vs DIRECT MEASUREMENT OF ICP THROUGH AN ICP PROBE IN ACUTE LIVER FAILURE PATIENTS - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/05/086883
Enrollment
20
Registered
2025-05-14
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G936- Cerebral edema

Interventions

Intervention1: NIL: NIL

Sponsors

Dr Abhiram Chandra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Both male & female Only adult patients aged 18 years and older will be included Patients must have a confirmed diagnosis of acute liver failure Patients with GCS is less than 14 Patients displaying altered sensorium or changes in mental status

Exclusion criteria

Exclusion criteria: History of glaucoma Some disease of the optic nerve Patients with SPONTANEOUS ICH/SDH in the setting of ALF

Design outcomes

Primary

MeasureTime frame
To determine the correlation between optic nerve sheath diameter (ONSD) measurements obtained via transorbital ultrasound and direct intracranial pressure (ICP) values obtained from invasive ICP probe monitoring in patients with acute liver failure (ALF).Timepoint: At insertion, day1, day2, day3—

Secondary

MeasureTime frame
ICU Stay DurationTimepoint: From admission until discharge or death.;Neurological status changesTimepoint: At baseline, Day1, Day2, Day3;Any treatment Interventions like medication adjustments & surgical proceduresTimepoint: From admission until discharge—

Countries

India

Contacts

Public ContactDr Abhiram Chandra

Asian Institute Of Gastroenterology

drabhiramg@gmail.com9885787801

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026