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Effectiveness of calorie restricted diet combined with resistance training versus unrestricted physical activity on liver fat content in patients with non alcoholic fatty liver: A RCT

Effectiveness of calorie restricted diet combined with structured resistance training versus ad libitium physical activity on hepatic steatosis in patients with non-alcoholic fatty liver: A RCT. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086849
Enrollment
140
Registered
2025-05-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K760- Fatty (change of) liver, not elsewhere classified

Interventions

Intervention1: STRUCTURED RESISTANCE TRAINING EXERCISE: structured resistance training is a carefully planned and organized exercise regimen under the guidance of a physiotherapist aimed at improving

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient aged between 18-65 years 2. Newly diagnosed cases of non-alcoholic fatty liver via transient elastography 3. Ability to give informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Any known secondary liver disease, including hepatitis B surface antigen or anti-hepatitis C virus antibodies. 2. Excessive alcohol consumption 3. Administration of medical treatment that may elevate alanine aminotransferase (ALT) or lead to hepatic steatosis (Drugs like amiodarone, risperidone, olanzapine, and valproic acid, etc). 4. Known diabetes and on multiple oral hypoglycaemic agents, or insulin. 5. Pregnant females, irrespective of gestational age. 6. Major chronic diseases including: renal, cardiovascular, lung, uncontrolled hypertension, inflammatory bowel disease, any malignancy and autoimmune disorders. 7. Orthopaedic contraindications for structured resistance training.

Design outcomes

Primary

MeasureTime frame
effectiveness of calorie-restricted diet combined with structured resistance training versus ad libitium physical activity on hepatic steatosis as assessed by Controlled Attenuation Parameter values in patients with non-alcoholic fatty liverTimepoint: BASELINE, 1MONTH, 3MONTH AND 6 MONTHS

Secondary

MeasureTime frame
changes in Anthropometric, Body composition, Cardiometabolic, Biochemical parameters and hand grip strength among both the groupsTimepoint: BASELINE, 1MONTH, 3MONTH AND 6 MONTHS

Countries

India

Contacts

Public ContactMonika Maan

Institute of Liver and Biliary Sciences

principalcon@ilbs.in8920288088

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026