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Impact of single and multiple visits root canal therapy in pain score in patient with Symptomatic Irreversible Pulpitis with Symptomatic Apical Periodontitis.

Effect of single and Multiple visits root canal therapy on levels of NLRP3, Substance P,and pain score in patient with Symptomatic Irreversible Pulpitis with Symptomatic Apical Periodontitis - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086835
Enrollment
30
Registered
2025-05-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: Single visit root canal therapy: Single visit root canal therapy with protaper ultimate file system Control Intervention1: Multiple visit root canal therapy: Mul

Sponsors

Adinath Talekar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.AGE 18 40 yr. 2.Selected tooth PERMANENT MANDIBULAR 1ST AND 2ND MOLARS 3.Patients with of Symptomatic Irreversible pulpitis with Symptomatic Apical Periodontitis. (according to the AAE guidelines) 4.ASA Physical Status I or II

Exclusion criteria

Exclusion criteria: 1.Systemic conditions affecting inflammation 2.Pregnancy/lactation 3.Previous endodontic treatment 4.Previously initiated treatment 5.Root resorption 6.Non-restorable teeth 7.Periodontal pocket depth > 4mm 8.Mobile teeth 9.Cracked teeth 10.Antibiotics/NSAIDs use within the past 2 weeks

Design outcomes

Primary

MeasureTime frame
Reduction in pain levelTimepoint: 7 days—

Secondary

MeasureTime frame
changes in pain levelsTimepoint: 7 days—

Countries

India

Contacts

Public ContactDax Abraham

Manav Rachna Dental College Faridabad

daxabraham.sds@mrei.ac.in9910433111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026