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Analysis of Salivary compounds in patients with gum disease having high Blood pressure

Estimation of Salivary volatile organic compounds in hypertensive subjects with periodontitis using Gas chromatography- Mass Spectrometry - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086832
Enrollment
120
Registered
2025-05-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: I00-I99- Diseases of the circulatory system

Interventions

Intervention1: Non surgical periodontal therapy: Scaling and Root planing Control Intervention1: Pre-hypertensives with periodontitis: Scaling and root planing Control Intervention2: Stage I hypertens

Sponsors

Manav Rachna Dental college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group A Pre-Hypertensive periodontitis subjects 1.Generalised periodontitis 2.Age between 30 to 60 years 3.Bleeding on probing 4.Pre-hypertension subjects according to AHA classification 5.Patient willing to participate in the study Group B- Stage I Hypertensive periodontitis subjects 1. Generalized periodontitis 2. Age between 30 to 60 years 3.Stage I Hypertension according to AHA guidelines 4.Patient willing to participate in the study Group C- Stage II Hypertensive periodontitis subjects 1. Generalized periodontitis 2. Age between 30 to 60 years 3. Stage II hypertension according to AHA guidelines 4.Patient willing to participate in the study

Exclusion criteria

Exclusion criteria: 1. Periodontal therapy last 3 months. 2. Antibiotics in last 3 months. 3. Pregnant and lactating females. 4. Subjects using any form of tobacco. 5. History of nasal obstructions and mouth breathers 6. History of known systemic diseases except hypertension 7. History of use of mouthwashes 8. Subjects using Dental prosthesis

Design outcomes

Primary

MeasureTime frame
The present study is undertaken to facilitate investigation to clarify the role of volatile organic compounds measurement with the help of GC-MS in causing oral malodour in obese hypertensive subjects with and without periodontitis.Timepoint: The recording of clinical parameters , saliva collection and estimation of volatile sulphur compounds measurement with the help of GC-MS at baseline and 1 month—

Secondary

MeasureTime frame
To compare the salivary VOC levels and clinical parameters in hypertensive with periodontitis subjects among all groups using GC- MS.Timepoint: 1 month—

Countries

India

Contacts

Public ContactLipika Gopal

manav rachna dental college

lipikagopal@yahoo.com9717546141

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026