Health Condition 1: D561- Beta thalassemia
Conditions
Interventions
Intervention1: Arginine Sodium flouride varnish: 2% Arginine mixed with 5% Sodium flouride varnishfrom baseline to 9 months (quarterly/ biannually)
Control Intervention1: Sodium Flouride varnish: 5%
Sponsors
Dr Shubhangi
Eligibility
Inclusion criteria
Inclusion criteria: 1.Beta thalassemia major participants enrolled from the department of medicine (Hematology), Post Graduate Institute of Medical Sciences, Rohtak , Haryana. 2. Participants aged between 12 years and 45 years. 3. Participants who gave written consent for the study. 4.Beta Thalassemia major participants with Nyvad and ICDAS score 2 and 3.
Exclusion criteria
Exclusion criteria: 1.Participants with other systemic disorders like serious or unstable cardiac, renal diseases, hypertensive, pulmonary, endocrine disorders. 2. Teeth with pulp involvement. 3. Presence of an abscess or sinus , obvious discolouration or premature hypermobility . 4. Patients under immunosuppressive drugs. 5.Patients who will not give consent. 6. Uncooperative patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Caries arrest rate from baseline using Nyvad Criteria and ICDAS at 6, and 12 months. Incidence of dental caries at 6 and 12 months. Biochemical changes i.e. salivary urea, iron, pH and TBARS at 3,6, 9 and 12 months. 4.Caries preventive fraction at 6 and 12 months. 5.Change in salivary Streptococcus mutans and Streptococcus sanguis count at 6 and 12 months.Timepoint: 0,3,6,9,12months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The patient satisfaction & acceptability of the preventive treatment & any side effects if any will be recorded. 2. The number needed to treat & the Intention to treat is calculatedTimepoint: baseline, 3,6,9,12 months | — |
Countries
India
Contacts
Public ContactShubhangi
Postgraduate Institute of Dental Sciences, Rohtak
Outcome results
None listed