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Fractional CO2 Laser versus Q-Switched Nd:YAG Laser in Melasma

Comparing the Efficacy of Combination of Q-Switched Nd:YAG and Fractional CO2 Lasers versus Q-Switched Nd:YAG Laser alone in Melasma: A Split-face Randomised Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086774
Enrollment
48
Registered
2025-05-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L811- Chloasma

Interventions

Intervention1: Fractional Co2 laser, Q-switched Nd:YAG laser: The combination treatment has been found to be better than either one in few studies with better efficacy and fewer side effects. We wish

Sponsors

AIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Clinically diagnosed Melasma

Exclusion criteria

Exclusion criteria: Any one of the following- 1. Pregnant and/ or lactating women 2. Women taking oral contraceptives or hormonal replacement therapy 3. Patients taking oral or topical treatment for Melasma 4 weeks prior to the study 4. Any known systemic illness 5. Active skin disease present locally 6. History of Photosensitive disorder 7. Patients having keloidal tendency 8. Bleeding diathesis 9. Unwilling to participate

Design outcomes

Primary

MeasureTime frame
Comparing efficacy of both groups by the change in modified MASI score and Physician Global Assessment (PGA) score.Timepoint: At each follow up visit. Final assessment will be done 2 weeks after the last session.

Secondary

MeasureTime frame
1. To assess dermoscopic changes in both treatment groups. 2. To observe and assess side effects in both treatment groups 3. To evaluate patient satisfaction using a percentage-based scoring systemTimepoint: At each follow up visit. Final assessment will be done 2 weeks after the last session.

Countries

India

Contacts

Public ContactPiyush Meena

AIIMS Jodhpur

anilbuddy25@gmail.com9213361424

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026