A Study comparing Titanium-platelet rich fibrin membrane with Bone graft vs Collagen Membrane with Bone Graft to manage bone loss between roots of teeth.

Comparative evaluation of Titanium-platelet rich fibrin membrane and Collagen membrane along with Nanohydroxyapatite graft for the management of Grade II Furcation defects: A clinico-radiographic study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086688

Enrollment

Registered

2025-05-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Nanocrystalline hydroxyapatite graft (Sybograf ) with T-PRF membrane.: In Open flap debridement Grade II Furcation defects will receive a Nanocrystalline hydroxyapatite graft (Sybograf

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients exhibiting atleast one Glickman s Grade II Furcation defect with Horizontal probing depth more than or equal to 3mm, vertical probing depth more than or equal to 5mm after evaluation of phase-I therapy 2. Radiographic evidence of inter-radicular bone loss. 3. Patient willing for surgery and ready to give written consent.

Exclusion criteria

Exclusion criteria: 1. Systemic illness known to affect the outcomes of periodontal therapy. 2. History of intake of antibiotics or other medications affecting the healing of periodontium in preceding 6 months. 3. Smokers, pregnant/lactating patients & patients with malocclusion will be excluded. 4. Platelet count less than 1,50,000/mm3 5. Patients with mobility of tooth more than or equal to Grade II. 6.Patients allergic to medications.

Design outcomes

Primary

Measure	Time frame
1. Full mouth Turesky Gilmore Modified Quigley Hein Plaque Index 2. Site specific Sulcus bleeding index (SBI) (Muhlemann et al 1971) 3.Site specific Probing pocket depth (PPD) 4. Relative vertical clinical attachment level (RVCAL) 5. Relative horizontal clinical attachment level (RHCAL) 6.Gingival margin level (GML) 7. Radiographic bone fillTimepoint: 3 and 6 months after surgery	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Shivani Karmalkar

SMBT Dental College and Hospital

lisabrahamj@gmail.com7378488875

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026