A special membrane used to collect samples from the eye surface to test for corneal ulcers

Corneal Impression Membrane (CIM) Sampling for Microbial Keratitis Diagnosis - CIMS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086646

Enrollment

Registered

2025-05-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: Using corneal impression membrane for obtaining material for diagnostic investigations: Under topical anaesthesia, corneal impression membrane will be used to obtain samples for - a)Sme

Eligibility

Inclusion criteria

Inclusion criteria: Suspicion of Fungal Keratitis and Undergoing routine corneal scraping for diagnostic purposes

Exclusion criteria

Exclusion criteria: Suspected Viral, Acanthamoeba, Mixed Keratitis cases Microbial Keratitis in both eyes Perforated ulcer Small ulcer of less than 3 mm

Design outcomes

Primary

Measure	Time frame
To demonstrate at least 65% sensitivity of CIM in detecting fungal organisms, thereby proving a non-inferiority of CIM to conventional corneal scraping method. To demonstrate that CIM collected specimens can be used for immediate identification of organisms by smear microscopy. Timepoint: The microbiology positivity will be checked at Day 1, 3 days, 1 week and 2 weeks.	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactJosephine Christy

Aravind Eye Hospital

josephine@aravind.org9994549584

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026