Health Condition 1: F331- Major depressive disorder, recurrent, moderate
Conditions
Interventions
Intervention1: Low FODMAP diet: Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols. These short-chain carbohydrates are poorly absorbed in the small intestine and can cause dige
Sponsors
Department of Health Research Multidisciplinary Research Unit at AIIMS Bhopal DHRMRU
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults aged 18-65 years. 2. Scores more than or equal to 4 each on domain one (depression) and domain five (somatic symptoms) of DSM-5 Cross-Cutting Symptom Measure Level 1 3. Ability to understand and adhere to a dietary intervention (low FODMAP diet).
Exclusion criteria
Exclusion criteria: 1. Severe medical conditions affecting the gastrointestinal system, kidney, or liver function. 2. History of substance use except nicotine. 3. Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.The proportion of patients with reduced depressive and somatic symptoms is in two arms. 2.A proportion of patients showing changes in urinary biomarkers, including tryptophan and its metabolites (5-HIAA, kynurenine, quinolinic acid) Timepoint: baseline and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between depressive and somatic Symptoms with urinary biomarkers, including tryptophan and its metabolites (5-HIAA, kynurenine, quinolinic acid) Timepoint: baseline and 4 weeks | — |
Countries
India
Contacts
Public ContactDr Roshan F Sutar
AIIMS Bhopal
Outcome results
None listed