Health Condition 1: M628- Other specified disorders of muscle
Conditions
Interventions
None listed
Sponsors
ICMR
Eligibility
Inclusion criteria
Inclusion criteria: Older adults greater than 60 years old, both males and females, and able to walk independently. Having SARC-F scores greater than 4 Having a smartphone and proficient in using a smartphone. Willing to provide written informed consent and willing to comply with study procedures.
Exclusion criteria
Exclusion criteria: Known cases of chronic kidney disease, chronic liver disease, primary, malignancy, osteoarthritis, HIV, on ICD and stroke. Diagnosed cases of psychiatric disorders like severe depression, or any psychiatric illness that impairs interaction with others. Active bacterial infections or sepsis as per IDSA guidelines , Cases of exfoliative Skin infections.,Recent trauma, fractures, Major surgeries (CABG, lower limb hip or knee replacement, renal transplants ) ,musculoskeletal pains or any dysfunction that prevents exercise. Subjects on anabolic steroids, glucocorticoids, chemotherapy, antituberculosis drugs and thyroxine. Known contraindications for SSPS as per Ayurveda texts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short Physical Performance Battery (SPPB): The Short Physical Performance Battery (SPPB) is an assessment tool that evaluates lower limb function through three components: balance tests, gait speed assessment, and chair rise exercises. Diminished SPPB scores suggest reduced physical capability and have been associated with sarcopeniaâ??a condition characterized by loss of muscle mass and strengthâ??as well as other negative health outcomes.Timepoint: baseline; months 1,2,3,4,5,6 (endpoint) | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA): The MoCA test is a brief screening tool used to detect mild cognitive impairment and early dementia in elderly populations. It assesses various cognitive domains including memory, attention, language, visuospatial skills, executive function, and orientation.Timepoint: baseline; months 1,2,3,4,5,6 (endpoint); Mini Nutritional Assessment (MNA): The MNA is a screening tool designed to assess the nutritional status of older adults, aiding in the early detection of malnutrition or the risk of malnutrition.Timepoint: baseline; months 1,2,3,4,5,6 (endpoint); SarQOL (Sarcopenia and Quality of Life): The SarQOL is a tool designed to measure the impact of sarcopenia on the quality of life in older adults.Timepoint: baseline; months 1,2,3,4,5,6 (endpoint);Pittsburgh Sleep Quality IndexTimepoint: baseline; months 1,2,3,4,5,6 (endpoint);Geriatric Depression ScaleTimepoint: baseline; months 1,2,3,4,5,6 (endpoint);Appendicular Skeletal Muscle Mass (ASM): Appendicular skeletal muscle mass (ASM) will be measured using bioelectrical impedance analysis (BIA), which is an essential tool for assessing muscle mass.Timepoint: baseline; months 1,2,3,4,5,6 (endpoint);Oxidative Stress(MDA, GSH-PX, SOD, eNOS, XO, Irisin, Myostatin, TGF-B1, GDF-15), Inflammatory markers using multiplex kitTimepoint: Baseline; End of 6th month(endpoint);Liver Function Test (LFT), Kidney Function Test (KFT)Timepoint: baseline; 1 month, 3 month, 6 month (endpoint);Addenbrooke Cognitive ExaminationTimepoint: baseline; months 1,2,3,4,5,6 (endpoint);Muscle Strength (Handgrip Strength): Muscle strength will be assessed using a handheld dynamometer. Handgrip strength is a simple and commonly used measure of upper-extremity muscle strength, typically measured using a handheld dynamometer. Handgrip strength is associated with overall muscle strength and is a reliable indicator of functional status in older adults. Low handgrip strength is associated with an increased risk of disa | — |
Countries
India
Contacts
Public ContactSriloy Mohanty
All India Institute of Medical Sciences - Rishikesh
Outcome results
None listed