Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Succinylcholine: Inj.Succinylcholine is given intravenously as bolus at 1mg/kg, with intubation level paralysis occuring 45 to 60 seconds
Control Intervention1: Rocuronium: Inj.Rocuroni
Sponsors
Department of Emergency MedicineAIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Adults of 18 years and above requiring Rapid sequence Intubation ,their legally authorised representative willing to give a valid consent
Exclusion criteria
Exclusion criteria: Legally authorized representative unable or unwilling to give informed consent, Patients less than 18 years of age, Patients with history of cardiac arrest, Patients allergic to succinylcholine or rocuronium Pregnancy, Preexisting myopathies or myasthenia gravis, Preexisting hyperkalemia, Patients with massive edema, immobile jaw from injury or infection, Patients with oropharyngeal tumors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the success rate of first-attempt orotracheal intubation in patients receiving succinylcholine versus rocuronium assessed by the physician and confirmed by capnography curve consistent over 3 respiratory cycles.Timepoint: To compare the success rate of first-attempt orotracheal intubation in patients receiving succinylcholine versus rocuronium assessed by the physician and confirmed by monitoring capnography curve over 12 to 15 seconds (consistent over 3 respiratory cycles) as per ventilator settings of Respiratory rate in a range of 12 to 16 breaths per minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare 1.Intubation condition assessed by Copenhagen score 2.Percentage of patients intubated by alternative techniques 3.Intubation related complication in fifteen minutes Cardiac arrest, Arterial hypotension less than ninty mm Hg,Occurrence of new oxygen desaturation,Physician reported aspiration, Arrhythmia, Allergic reactionTimepoint: 1.Copenhagen score calculated at 45 to 60 seconds after administration of neuromuscular blocking agents 2.Alternative techniques of intubation will be used after failure of 3rd attempt of orotracheal intubation. 3.Intubation related complication such as Cardiac arrest, Arterial hypotension less than 90 mmHg,Occurrence of new oxygen desaturation,Physician reported aspiration, Arrhythmia, Allergic reaction are assessed within 15 minutes of post intubation | — |
Countries
India
Contacts
Public ContactDr Nayer Jamshed
AIIMS New Delhi
Outcome results
None listed