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Clinical trial of study the effect of two drug clonidine and magnesium sulphate in laparoscopic surgeries

Comparison of the effects of Intravenously Administered Clonidine and Magnesium Sulphate as Premedication on Attenuation of Hemodynamic Responses during Laparoscopic Surgeries after Pneumoperitoneum. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086524
Enrollment
80
Registered
2025-05-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: Intravenous Clonidine 1mcg/kg and Intravenous Magnesium Sulphate 50mg/kg: Monitoring Hemodynamic Responses During Laparoscopic Surgeries After Pneumoperitoneum Intervention2: General An

Sponsors

Department of Anaesthesia and Critical Care , Hind Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA- 1 and ASA-2 Elective Intra-Peritoneal Laparoscopic Surgeries

Exclusion criteria

Exclusion criteria: Patient Refusal Patient Allergic to Study Medications Pregnant Females Lactating Females Patient with Psychiatric Diseases Diabetic Patient with Autonomic Neuropathy Patient with Cardiovascular Disease, Renal Disease , Liver Disease Uncontrolled Hypertension

Design outcomes

Primary

MeasureTime frame
To Compare the Effect of Intravenous Administered Clonidine Versus Intravenous Magnesium Sulphate as Premedication for Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Blood Pressure After Carbon Dioxide Insufflations.Timepoint: Premedication for Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Blood Pressure After Carbon Dioxide Insufflations i.e. Preoperative, 5 mins After Giving Drug Till 15 mins, Baseline, Before Induction, Before Pneumoperitoneum, Every 5 mins Till 20 mins After Pneumoperitoneum, Then Every 10 mins Till 60 mins, Then Every 20 mins Till End of Surgery, 10 mins After Releasing CO2 and 10 mins After Extubation, Postoperatively Every Hour for 6 HRS.—

Secondary

MeasureTime frame
To Assess The Side-Effect of Intravenous Clonidine & Intravenous Magnesium Sulphate as Premedication Like Hypotension, Bradycardia, Decrease Urine Output.Timepoint: Monitor the Adverse Events of Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Blood Pressure After CO2 Insufflations i.e. Preoperative, 5 mins After Giving Drug Till 15 mins, Baseline, Before Induction, Before Pneumoperitoneum, Every 5 mins Till 20 mins After Pneumoperitoneum, Then Every 10 mins Till 60 mins, Then Every 20 mins Till End of Surgery, 10 mins After Releasing CO2 & 10 mins After Extubation, Postoperatively Every Hour for 6 HRS.—

Countries

India

Contacts

Public ContactDr Anand Yadav

Hind Institute of Medical Sciences

sudhir.rai17@gmail.com9455106967

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026