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Novel Herbal mouthrinse

Antibacterial Potential of Ethanolic extract of Spilanthes acmella Mouthrinse Against Salivary Streptococcus mutans in Young Adults of Pondicherry- A Double-blinded Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086516
Enrollment
60
Registered
2025-05-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

GShobana
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The subjects with atleast one active caries lesion. 2. The subjects with gingival and or/ periodontal disease 3. The subjects who brush only once daily. 4. the subject who signed informed consent to be recruited

Exclusion criteria

Exclusion criteria: Patients who received antibiotic therapy within past 3 weeks. 2. The subjects who had preventive dental procedures at last 48 hours. 3. The subjects those who had use mouth wash for past one month. 4. The subjects with limited manual dexterity and systemic illness. 5. Patients giving known history of allergy to any of the constituents of mouth rinses.

Design outcomes

Primary

MeasureTime frame
Reduction in Salivary Streptococcus mutans Colony Count Measured using colony-forming units per milliliter (CFU/mL) in saliva samples. Saliva samples collected at: oBaseline (Day 0) oAfter 30 days of intervention (Final) The primary outcome evaluates the effectiveness of Ethanolic extract of Spilanthes acmella herbal mouthrinse in reducing bacterial load compared to control groups (Chlorhexidine). Timepoint: Reduction in Salivary Streptococcus mutans Colony Count Measured using colony-forming units per milliliter (CFU/mL) in saliva samples. Saliva samples collected at: oBaseline (Day 0) oAfter 30 days of intervention (Final) The primary outcome evaluates the effectiveness of Ethanolic extract of Spilanthes acmella herbal mouthrinse in reducing bacterial load compared to control groups (Chlorhexidine).—

Secondary

MeasureTime frame
Validated feedback questionnaire at the end of the intervention. Evaluates participants perception of taste, aftertaste, & ease of use. Adverse Effects or Oral Discomfort are monitored during the study. Timepoint: At the end of 30 days, feedback to be collected from the participants—

Countries

India

Contacts

Public ContactDrGShobana

Sri Venkateshwaraa Dental college

drdinesh.d.s@gmail.com9443459210

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026