Health Condition 1: L811- Chloasma
Conditions
Interventions
Intervention1: Cream Metformin 4%: Cream Metformin 4% L/A OD HS for 3 months.
Control Intervention1: Cream Hydroquinone 4%: Cream Hydroquinone 4% L/A OD HS for 3 months.
Sponsors
Priyal Suhalka
Eligibility
Inclusion criteria
Inclusion criteria: All patients of Melasma aged 18 years to 50 years, who are not on medication of Melasma. Since atleast 2 weeks for topical therapy, 1month for systemic steroids, 3 months for cosmetic procedures such as laser ablation, dermabrasion, or peels.
Exclusion criteria
Exclusion criteria: 1 Pregnant and lactating women. 2 Patients on oral contraceptives or photosensitivity drugs (tetracycline, spironolactone, phenytoin, and carbamazepine) 3 Renal or liver dysfunction patients. 4 Allergic to the medications being given. 5 Acne Vulgaris and Rosacea patients along with Melasma. 6 Patients with Post inflammatory hyperpigmentation, neurodermatitis, eczema, atrophy, telangiectasia along with Melasma. 7 Patients with history of neoplastic conditions. 8 Patients on Metformin therapy for any reason. 9 Patients with abnormal BMI. 10 Patients not willing to give consent to participate in study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Through the current study, we will be able to compare efficacy and safety of 4% Topical Metformin with 4% Topical Hydroquinone in patients with Melasma in terms of modified MASI ScoreTimepoint: 0, 4th week, 8th week, 12th week | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparasion of Dermoscopic patterns in both the drugs. 2. Comparison of patient satisfaction in treatment with both the drugs in terms of Patient self assessment score. 3. To evaluate relapse rate in both the groups.Timepoint: 0, 4th week, 8th week, 12th week | — |
Countries
India
Contacts
Public ContactPriyal Suhalka
Geetanjali Medical College and Hospital, Udaipur
Outcome results
None listed