Health Condition 1: S299- Unspecified injury of thorax
Conditions
Interventions
Intervention1: Observational study (chest trauma severity scoring assessment and blood sample collection for mitochondrial dna estimation): Chest trauma severity assessment and blood collection for mi
Sponsors
Department of anaesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient admitted to the emergency department within 24 hours 2. Patients with clinical symptoms and pulmonary infiltrative shadows 3. Patients requiring mechanical ventilation support 4. Patients with chest trauma with trauma as a causative factor; confirmation of blunt trauma based on clinical evaluation and diagnostic imaging (e.g., chest x-ray, ct scan) 5. Availability of blood samples for mitochondrial dna (mtdna) analysis at the time of admission or shortly thereafter 6. Written informed consent obtained from patients or legally authorized representatives for participation in the study
Exclusion criteria
Exclusion criteria: 1) Patients with penetrating chest trauma (e.g., gunshot wounds, stab wounds) as the primary mechanism of injury. 2) Patients with pre-existing medical conditions or comorbidities known to affect mtDNA levels or alter prognostic outcomes (e.g., chronic inflammatory disorders, mitochondrial diseases). Patients with severe traumatic brain injury or other injuries requiring immediate surgical intervention, potentially confounding the assessment of blunt chest trauma outcomes. 3) Patients with history of Chronic lung disease, Autoimmune diseases, infections 4) Patients with history of Lung Surgery 5) Patients with ARDS with Non-Traumatic causes 6) Patients with active Bleeding conditions Patients with incomplete medical records or missing data necessary for the evaluation of clinical outcomes and severity scoring. 7) Pregnant patients, as pregnancy-related changes in mtDNA levels could introduce confounding variables in the analysis. 8) Patients who decline or are unable to provide informed consent for participationPatients transferred from other healthcare facilities with incomplete documentation of injury mechanism or clinical management prior to arrival. in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To Compare Chest Trauma Severity Scoring with Levels of Circulating DNA as a prognostic MarkerTimepoint: 1. Day of Admission( Day 1) 2. 3 rd Day 3. 7 th day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) 28 days Mortality 2) Ventilatory Free days 3)Requirement of Mechanical ventilator support 4) Evaluate the association between circulating mtDNA levels and clinical outcomes in chest trauma patients. 5) Compare the prognostic efficacy of mtDNA levels with traditional clinical findings such as vital signs, physical examination, and imaging studies. 6) Investigate the feasibility of incorporating mtDNA analysis into routine prognostic assessments for chest trauma patients.Timepoint: 1. Day of Admission( Day 1) 2. 3 rd Day 3. 7 th day | — |
Countries
India
Contacts
Public ContactKavita Meena
Institute of medical sciences Banaras Hindu university varansi 221005
Outcome results
None listed