Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Lignocaine group (Group L): Patients in the Lignocaine group (Group L) will receive an IV bolus of lignocaine preservative-free 1.5 mg/kg just before induction followed by 2mg/kg/hour i
Sponsors
Sir Gangaram Hospital
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anaesthesiologists (ASA) physical status I and II Body Mass Index = 18.5-35 kg/m2 Glasgow Coma Score 15
Exclusion criteria
Exclusion criteria: Refusal to give consent for participation History of allergy to medications to be used in the study Patient routinely taking opioids within last 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare cumulative intraoperative fentanyl consumption in patients undergoing supratentorial tumor resection surgery under general anesthesia, with either intravenous lignocaine infusion or placebo.Timepoint: To compare cumulative intraoperative fentanyl consumption in patients undergoing supratentorial tumor resection surgery under general anesthesia, with either intravenous lignocaine infusion or placebo during skull pin insertion T1, during incision T2, and during any time in the intraoperative period. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare the incidence of fentanyl-related side effects, including postoperative nausea, and vomiting (PONV) during the first 24 hours postoperatively between the two study groups. 2.To compare the rescue analgesic requirements during the first 24 hours postoperatively between the two groups, evaluating the effect of intravenous lignocaine infusion on analgesic consumption. Timepoint: immediately after extubation, one-hour post-extubation in the Post-Anaesthesia Care Unit (PACU), and subsequently at 6 hours, 12 hours, 18 hours, and 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactArindam Dubey
Sir Gangaram Hospital
Outcome results
None listed