The effect of fractional CO2 laser in combination with topical insulin in treatment of facial atrophic acne scars

The safety and efficacy of Fractional CO2 laser with topical insulin versus Fractional CO2 laser alone in facial atrophic post-acne scar: A randomized split-face study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086346

Enrollment

Registered

2025-05-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: Fractional CO2 with Topical insulin: In each visit, the Fractional CO2 Laser (Fotona, SP Dynamics) with parameters Wavelength-10600nm, point energy- 8 mJ, 8W, residence time- 1ms, Inte

Eligibility

Inclusion criteria

Inclusion criteria: Atrophic post Acne scar of any grade Fitzpatrick skin type 3 to 6 No treatment (including surgical and laser therapy) within 12 weeks before being enrolled in the study.

Exclusion criteria

Exclusion criteria: Pregnancy and lactation Autoimmune disease, connective tissue disease History of Photosensitivity Use of immunosuppressive medications, active cancer, underlying illness (cardiac, neurological) History of skin cancers, and presence of premalignant or malignant cutaneous lesions over the face. History of keloidal tendency Patient on isotretinoin therapy Presence of hypertrophic scars History of diabetes mellitus

Design outcomes

Primary

Measure	Time frame
To Compare the efficacy of topical insulin with fractional CO2 laser versus fractional CO2 alone in the treatment of PAS.Timepoint: 0 week,4 weeks,8 weeks,12 weeks	—

Secondary

Measure	Time frame
To Assess the safety of topical insulin with fractional CO2 laser in the treatment of PAS. To Assess the effect of topical insulin with fractional CO2 laser therapy on the quality of life in PAS patients Timepoint: 0 week,4 weeks,8 weeks,12 weeks	—

Countries

India

Contacts

Public ContactBikash Ranjan Kar

IMS AND SUM HOSPITALS

bikashkar@soa.ac.in9937428181

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026