Health Condition 1: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Manipal Institute of Virology
Eligibility
Inclusion criteria
Inclusion criteria: Only symptomatic individuals with Acute respiratory infection (ARI)/ Severe Acute respiratory infection (SARI)/ Lower respiratory tract Infection (LRTI) from both inpatients and outpatients are considered. Along with the routine samples that come to the virology department for testing under the same case definition Parents/guardians/attending physicians must provide informed consent for infants/children participants and for adult participants; they themselves must provide informed consent or their guardians/attending physicians must provide consent on behalf of them to participate in this study.
Exclusion criteria
Exclusion criteria: Individuals with a confirmed clinical diagnosis who do not fulfill the specified case definition. Individuals who have not provided consent to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study will determine the prevalence and burden of RSV across all age groups, identify circulating RSV-A and RSV-B strains through partial genome sequencing, assess the correlation between RSV viral load and clinical outcomes using quantitative PCR, contribute to molecular surveillance, and support development of monoclonal antibodies targeting the RSV Fusion (F) protein for diagnostic and therapeutic applications.Timepoint: 24 Months | — |
Secondary
| Measure | Time frame |
|---|---|
| This study will help us determine the prevalence, distribution, and burden of RSV infections across all age groups, including vulnerable populations, providing key epidemiological data to support public health strategies. This study will help us identify and characterize circulating RSV strains (RSV-A and RSV-B) through partial genome sequencing, tracking viral evolution, genetic diversity, and their association with disease severity. By this study we will be able to assess the correlation between RSV viral load and clinical outcomes, such as disease severity and symptom duration, using standardized PCR quantification. Also, we can analyze seasonal trends and contribute to RSV molecular surveillance for early outbreak detection and improved public health preparedness.Timepoint: 12 Months | — |
Countries
India
Contacts
Public ContactAnup Jayaram
Manipal Institute of Virology
Outcome results
None listed