Skip to content

Changes in protein levels in saliva of patients treated with invisible braces and metal braces

Changes in the levels of apolipoprotein E in saliva during clear aligner therapy and fixed orthodontic treatment - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086312
Enrollment
128
Registered
2025-05-05
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Clear Aligners: Assessment of levels of Apolipoprotein E in salivary samples of patients undergoing treatment with clear aligners Control Intervention1: Fixed Orthodontic Treatment: Ass

Sponsors

Sourav Hari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a)Age group from 15-30 years b) Bimaxillary protrusion cases that require extraction of all premolars for orthodontic correction. c) No history of antibiotics and anti-inflammatory drugs in past 6 months preceding study. d) Periodontally healthy with generalized probing depth less than or equal to 3 mm. e)Radiographic parameters of no signs of crestal bone loss on radiograph.

Exclusion criteria

Exclusion criteria: Presence of gingivitis and periodontitis b) Presence of Systemic disease c) Presence of bone disease d) History of previous orthodontic treatment e) Smoking habit

Design outcomes

Primary

MeasureTime frame
Changes in the level of Apolipoprotein ETimepoint: T0- Saliva collected at beginning of treatment T1 - Saliva collected 24 hours after intervention. T2- Saliva collected after 21 days of intervention T3 Saliva collected after 6 months of intervention

Secondary

MeasureTime frame
To compare both the groupsTimepoint: T0- Saliva collected at beginning of treatment T1 - Saliva collected 24 hours after intervention. T2- Saliva collected after 21 days of intervention T3 Saliva collected after 6 months of intervention

Countries

India

Contacts

Public ContactAshish Kumar Singh

Manav Rachna Dental College

aksingh.sds@mrei.ac.in8377878380

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026