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Effect of toxic metal lead on brain development of children

Evaluation of neurodevelopmental alterations induced by maternal and early life lead exposure - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/05/086294
Enrollment
160
Registered
2025-05-05
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil

Sponsors

Dr. Herman Sunil Dsouza
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Maternal blood sample Inclusion criteria Occupationally (Lead-based) exposed mother Age - 23-45 years Work experience more than or equal to 1 year Mothers having children between age of 5-15 years Inclusion criteria Age- 5-15 years Mother currently working in a lead-based occupation Maternal exposure more than or equal to 1 year

Exclusion criteria

Exclusion criteria: Exclusion criteria for mothers Age less than 23 years and more than 45 years Mothers having children less than 5 years and more than 15 years of age Undergoing chelation therapy Exclusion criteria for children Age- less than 5 years and more than 15 years Mothers who are not working in lead-based occupation Maternal exposure less than 1 year Undergoing chelation therapy Individuals unable to provide blood due to weakness or any other medical conditions

Design outcomes

Primary

MeasureTime frame
These outcome measures collectively aim to elucidate the relationship between lead levels and various factors, including behavioral, genetic, epigenetic, and biochemical, with a focus on understanding the potential impact on neurodevelopment in children.Timepoint: 2 weeks

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Herman Sunil Dsouza

Manipal School of Life Sciences

hs.dsouza@manipal.edu9448017901

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026