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Comparing Letrozole and Mifepristone For Early Medical Abortion: Effects on Expulsion rates in Participants.

Comparing Letrozole VS Mifepristone for First Trimester Medical Abortion: An Open Label Randomised Control Trial - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086254
Enrollment
130
Registered
2025-05-05
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Letrozole drug: Letrozole 10 mg OD for 3 days followed by misoprostol administration 800ug PV on Fourth day followed by 400ug misoprostol PV every 4 hourly till expulsion, Followed by f

Sponsors

Jagruti Shukla
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Women aged greater than 18 years wanting termination of pregnancy at less than or equal to 18 years of age. Not having any contraindication for medical abortion.

Exclusion criteria

Exclusion criteria: Women with known case of heart, liver,kidney disease Incomplete or inevitable abortion,suspected ectopic,hb less than 8 gm/dl,pateint on ATT etc

Design outcomes

Primary

MeasureTime frame
A high rate of complete uterine evacuation without the need for surgical intervention, comparable between the letrozole-misoprostol and mifepristone-misoprostol groups. Timepoint: Follow up on Day 7th and day 15th for evacaution rate

Secondary

MeasureTime frame
Misoprostol to tissue expulsion interval (hours) Pain score on the day of misoprostol administration Duration of bleeding after sac expulsion Level of bleeding after sac expulsion More than usual menstruation Same as menstruation Less than usual menstraution Fever/chills/Nausea/Vomiting/Abdominal cramps/ Diarrhoea Need for surgical evacuationTimepoint: Follow up on Day 7th and day 15th for evacaution rate

Countries

India

Contacts

Public ContactPreeti Bala Singh

AIIMS GORAKHPUR

preetikgmc@gmail.com7838514224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026