Recovery of adult molars with dental caries after treatment using Biodentine with or without Concentrated Growth Factors.

Outcomes of Vital Pulp Therapy in permanent molars with Symptomatic Irreversible Pulpitis using Biodentine with and without Concentrated Growth Factor: A Prospective Study - NIL

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086241

Enrollment

Registered

2025-05-05

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: Vital Pulp Therapy with Biodentine: Direct placement of Biodentine over pulp exposure after hemostasis, followed by permanent restoration and radiographic follow up for one year. Contro

Eligibility

Inclusion criteria

Inclusion criteria: 1 Medically uncompromised adults 2 Tooth with mature apex 3 Dental caries extending more than 2/3 of dentine diagnosed with Symptomatic Irreversible Pulpitis without involvement of Apical Periodontitis 4 Showing positive response to COLD TEST and EPT 5 Normal limits of probing depth and mobility

Exclusion criteria

Exclusion criteria: 1. Failure to achieve haemostasis within 10min after full pulpotomy. 2. Presence of pulpal necrosis - Swelling/ Sinus tract / Abscess. 3. Internal Root Resorption / External Root Resorption. 4. No pulp exposure after caries excavation or insufficient bleeding after pulp exposure, the pulp is judged necrotic or partially necrotic

Design outcomes

Primary

Measure	Time frame
The primary objective of this study is to evaluate the radiographic success of vital pulp therapy in permanent molars with symptomatic irreversible pulpitis by using Biodentine alone, Biodentine combined with Concentrated Growth Factors (CGF), and CGF alone. The study aims to assess dentinal bridge formation, pulp healing, and the absence of pathological changes as indicators of successful therapy.Timepoint: T1-24hrs T2-72hrs T3-3months T4-6months T5-1year	—

Measure

Time frame

The primary objective of this study is to evaluate the radiographic success of vital pulp therapy in permanent molars with symptomatic irreversible pulpitis by using Biodentine alone, Biodentine combined with Concentrated Growth Factors (CGF), and CGF alone. The study aims to assess dentinal bridge formation, pulp healing, and the absence of pathological changes as indicators of successful therapy.Timepoint: T1-24hrs T2-72hrs T3-3months T4-6months T5-1year

—

Secondary

Measure	Time frame
NilTimepoint: Nil	—

Countries

India

Contacts

Public ContactDr Divya Vincent

Inderprastha Dental College and Hospital

nidhisharma2503@yahoo.com9958100191

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026