Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: TOFR monitor will be used to find the residual paralysis: Reversal of neuromuscular block by assessing residual paralysis using TOFR monitor Before induc
Sponsors
Ashli Shaji
Eligibility
Inclusion criteria
Inclusion criteria: Elderly participants undergoing elective surgery of expected duration less than or equal to 3 hours under general anesthesia using neostigmine to antagonize vecuronium-induced muscle relaxation. Participants with ASA physical classification I and II who can provide informed consent
Exclusion criteria
Exclusion criteria: Patients with unexpected perioperative surgical complications, BMI greater than 30 Kg/m2, Patients who have planned postoperative ventilatory support, Patients with more than a 10% difference in two consecutive TOFR, History of neuromuscular, hepatic, and renal disorders, known allergy to neostigmine and vecuronium, usage of the drugs affecting neuromuscular transmission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the optimal dose of Neostigmine to antagonize Vecuronium-induced neuromuscular blockade by assessing residual paralysis using a Train of four ratio V/S clinical assessment tests in geriatric patientsTimepoint: Before induction of general anaesthesia, immediately after intubation 5-15 minutes, Pre-reversal phase, at the time of tracheal extubation, post-extubation period of 5-15 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate the occurrence of intraoperative complications of residual muscle paralysis and potential risk factors of an inadequate dose of neostigmine as the reversal agent in geriatric patientsTimepoint: Before induction of general anaesthesia, immediately after intubation 5-15 minutes, Pre-reversal phase, at the time of tracheal extubation, post-extubation period of 5-15 minutes;To assess the association of intraoperative factors influencing the residual effects of Vecuronium in geriatric patientsTimepoint: Before induction of general anaesthesia, immediately after intubation 5-15 minutes, Pre-reversal phase, at the time of tracheal extubation, post-extubation period of 5-15 minutes | — |
Countries
India
Contacts
Public ContactAshli Shaji
Srinivas University, Institute of Allied Health science, Mukka, Mangaluru
Outcome results
None listed