Health Condition 1: K053- Chronic periodontitis
Conditions
Interventions
Intervention1: 0.1% Quercetin Chitosan Nanoparticle Gel: Local drug delivery in Periodontal Pocket for 7 days
Control Intervention1: Placebo Gel: Local drug delivery in Periodontal Pocket for 7 days
Sponsors
Nikesh Narayana Moolya
Eligibility
Inclusion criteria
Inclusion criteria: Systemically healthy subjects with a minimum of 20 teeth. Subjects with moderate chronic periodontitis and no other gingival lesions. Subjects between the age group 35 to 60 years. No removable prosthesis or orthodontic bands or appliances worn at the time of study.
Exclusion criteria
Exclusion criteria: Subjects with a history of any antibiotics, anti-inflammatory or antimicrobial mouth rinse usage or periodontal therapy in the preceding 3 months or during the study period. Subjects with suspected allergy to any flavanoids, chitin based products, those on anticoagulant or steroid therapy, smokers, tobacco chewers, alcoholics, pregnant or lactating mothers. Immunocompromised patients, dental infections like chronic periapical lesions, apthous stomatitis, oral lichen planus, non-compliant or physically challenged patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Plaque Index (PI) (Silness J, Loe H,1964) 2. Gingival Index (GI) (Loe H, Silness J,1963) 3. Modified Sulcus Bleeding Index (SBI) (Mombelli 1987) 4. Probing Pocket Depth (PPD) (measured from crest of the gingival margin to the base of the pocket) and 5. Relative Clinical Attachment Levels (CAL) (measured from the lower border of acrylic stent to the base of the pocket) to be recorded only for the selected sites by using a customized acrylic stent. (with UNC-15 probe)Timepoint: Baseline and Postoperatively 45 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Collection of Unstimulated Whole Saliva(UWS) samples UWS to be collected at approximately the same time of day by the drooling method (Rhodus et al., 2005). Briefly, subjects asked to refrain from eating or drinking for 2 hours prior to saliva collection. At least 2ml of UWS to be collected by passively drooling into a chilled centrifuge tube for 5-10 minutes. The tubes to be codified and transferred on ice to the laboratory for processing. All samples to be centrifuged and the supernatant constituting clarified saliva to be separated and stored until further analysis. Unstimulated whole saliva (UWS) sampling to be conducted to evaluate IL-1L1 beta levels and samples will be sent to Department of Biotechnology and Bioinformatics for processing and analysis Timepoint: Baseline and Postoperatively 45 days | — |
Countries
India
Contacts
Public ContactNIKESH NARAYAN A MOOLYA
SMBT Dental College and Hospital Sangamner
Outcome results
None listed