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Study the efficacy of rTMS for drug naive patients with depression

Understanding the effects of cognitive circuit engagement and facilitation of dorsolateral prefrontal cortices activation while administering TMS in depression using a non inferiority study design and comparing to standard repetitive TMS protocol - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086231
Enrollment
72
Registered
2025-05-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F30-F39- Mood [affective] disorders

Interventions

Intervention1: Nil: Nil

Sponsors

Biotechnology Industry Research Assistance
Lead Sponsor
Indian Institute of Technology Kanpur
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: - Willing to give informed consent to the study - Local to Kanpur and can visit the department of cognitive science, IIT Kanpur at least 5 days a week for rTMS - Drug naive patients - Clinically diagnosed with Depression according to ICD 10 DCR

Exclusion criteria

Exclusion criteria: - Individuals not giving informed consent - Presence of metals in the body - Severe depression with psychotic symptoms - Active suicide ideation - Unable to visit the rTMS lab, IIT Kanpur - Dipolar depression, substance use disorder (excluding nicotine), pregnancy or post-partum period - Untreated co-morbidities that require immediate surgical or medical assistance - History of seizure disorder - Intellectual disability - shall be ruled out clinically

Design outcomes

Primary

MeasureTime frame
Change in PHQ9/HAM-D scores from baseline for rTMS+meds vs only medsTimepoint: 4-6weeks—

Secondary

MeasureTime frame
Electrophysiological changes for rTMS_meds vs only medsTimepoint: 4-6 weeks—

Countries

India

Contacts

Public ContactPragathi Priyadharsini Balasubramani

Indian Institute of Technology Kanpur

pbalasub@iitk.ac.in09842109697

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026