Using Ozone and Laser Light to Help Heal Advanced Gum Disease in Diabetic Patients

Adjunctive ozone and light amplification by stimulated emission of radiation Photobiomodulation therapy in managing StageIII/IV grade B Periodontitis in Patients With Type II Diabetes Mellitus A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086216

Enrollment

Registered

2025-05-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Adjunctive Ozone and light amplification by stimulated emission of radiation Photobiomodulation Therapy in Managing Stage III/IV Grade B Periodontitis in Patients with Type II Diabetes

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients diagnosed with localized/generalized periodontitis stage III or IV, grade B. 2.Dental Health:Presence of at least 12 teeth distributed in all four quadrants. 3.Presence of residual periodontal pockets greater than or equal to 6mm. 4.Presence of interproximal defects on single-rooted teeth or molars without extension to the furcation area and associated with intrabony greater than 3 mm. 5.Systemic Health: Diagnosed with Type II Diabetes Mellitus with controlled blood glucose levels

Exclusion criteria

Exclusion criteria: 1.Pregnancy and Lactation: Females who are pregnant or breastfeeding 2.Systemic Conditions .Presence of a cardiac pacemaker.Epilepsy or neuro-psychological disorders. 3.Medications:benzodiazepines, and corticosteroids. proton pump inhibitors serotonin reuptake inhibitors. 4.Smokers or use of other tobacco products. 5.uncontrolled Diabetes with HbA1ac greater than7. 6.Surgical intervention in the last 12 months. 7.Undergoing periodontal surgery at the experimental sites.

Design outcomes

Primary

Measure	Time frame
If adjunctive therapies prove beneficial, clinicians could improve the quality of life for patients with severe periodontitis and type II DM. Effective treatments may reduce disease progression, enhance tissue regeneration, and promote better oral health. Timepoint: within 6 months improvement in oral health	—

Secondary

Measure	Time frame
within 6 months improvement in oral healthTimepoint: within 6 months improvement in oral health	—

Countries

India

Contacts

Public ContactDr Dhirendra kumar Singh

kalinga institute of dental sciences

drjalal1979@gmail.com9338131843

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026