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Effect of two remineralising pastes in treatment of tooth hypersensitivity

Efficacy of Nano-hydroxyapatite and Fluoro Calcium Phosphosilicate Dentifrices in Treatment of Dentin Hypersensitivity: A Double-Blind Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086212
Enrollment
141
Registered
2025-05-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K039- Disease of hard tissues of teeth,unspecified

Interventions

Intervention1: Nano-hydoxyapatite Toothpaste: Pea-sized nano-hydroxyapatite toothpaste brushing for 2 minutes Intervention2: Fluoro calcium phosphosilicate toothpaste: Pea- sized fluoro calcium phosph

Sponsors

SRM Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Males and females presenting with symptoms of dentin hypersensitivity in the age group of 18-60 years. 2. Non-carious cervical defect of at least 1x1mm and not deeper than 1.5 mm; no previous restorations. 3. At least one sensitive tooth with exposed buccal cervical dentin anterior to molars on either side of the midline due to erosions or abrasions with or without an associated gingival recession. 4. To be eligible for enrolment, the subject must have recorded a response of 4 cm that is score 4 or more on a 10 cm VAS scale on the tooth of interest to a 2-second blast of air from an air-water syringe. 5. Subjects giving a minimum of 2 in Schiff s Sensitivity Scale (air blast/cold stimuli) during the baseline examination. 6. Patients with GI and PI score of 0 and 1.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic illness 2. Use of any desensitizing therapy within the previous 3 months 3. Systemic conditions that are etiologic to DH (e.g., chronic acid regurgitation) 4. Use of medications that interfere with the perception of pain like chronic use of anti-inflammatory, analgesic, anticonvulsant, sedative or other psychotropic drugs 5. Pregnancy or breastfeeding 6. Active periodontitis/ periodontal abscess, mobility, or pain from periodontal-related causes or occlusal trauma 7. Patients with history of parafunctional habits like bruxism 8. If the sensitive tooth was restored in the previous 3 months or served as an abutment for a fixed or removable dental prosthesis 9. Smokers

Design outcomes

Primary

MeasureTime frame
Pain using Visual analog scaleTimepoint: 2 weeks, 4 weeks and 3 months

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr S Mahalaxmi

SRM Institute of Science and Technology

vidhyas@srmist.edu.in9445563355

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026