A study to compare the effect of a special resveratrol-based nanofiber film placed in gum pockets, along with routine dental cleaning, in patients with long-term gum disease.

Comparative Evaluation of Electrospun Resveratrol-Loaded Nanofibers as a Local Drug Delivery System Adjunctive to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086178

Enrollment

Registered

2025-05-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Electrospun Resveratrol-Loaded Nanofiber : SRP followed by Electrospun Resveratrol-Loaded Nanofiber Film - Applied subgingivally into periodontal pockets after scaling and root planing

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults aged 25 to 60 years 2. presence of greater than or equal to 20 teeth 3. Probing depth greater than or equal to 5mm in at least 4 sites 4. Diagnosed with chronic periodontitis

Exclusion criteria

Exclusion criteria: 1.Systemic illness 2. Antibiotics or periodontal treatment in past 6 months 3.Pregnancy/lactation 4.Allergy to resveratrol

Design outcomes

Primary

Measure	Time frame
eduction in probing pocket depth (PPD) - Gain in clinical attachment level (CAL)Timepoint: Baseline, 1 month and 3 months	—

Secondary

Measure	Time frame
Bleeding on probingTimepoint: Bleeding on probing - Baseline, !month and 3 months	—

Countries

India

Contacts

Public ContactMaria Sharon velraj

Saveetha institute of medical and technical sciences

arvinar.sdc@saveetha.com8124448902

Outcome results