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Early dialysis compared to standard care in sick children with infection and hypotension

Early continuous renal replacement therapy versus standard care in critically ill children with septic shock: A pilot, single-centre, open-label, randomized controlled trial - CRISIS Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086174
Enrollment
60
Registered
2025-05-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I959- Hypotension, unspecified

Interventions

Intervention1: Early CRRT: Early continuous renal replacement therapy will be performed in addition to standard care in children with catecholamine-resistant septic shock Control Intervention1: Standa

Sponsors

AIIMS Raipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Catechomaline-resistant septic shock

Exclusion criteria

Exclusion criteria: Anticipated PICU stay less than 24 hours, Need of renal replacement therapy at PICU admission as per conventional indications, did not give informed consent

Design outcomes

Primary

MeasureTime frame
MortalityTimepoint: 28 days—

Secondary

MeasureTime frame
Duration of inotropic support (hours) Ventilator-free days (VFDs) Trend of paediatric SOFA scores Duration of PICU stay, PICU free days Duration of hospital stay Survival at hospital discharge Need of RRT at 3 months follow-up Timepoint: 7 days, PICU discharge, hospital discharge, 3 months—

Countries

India

Contacts

Public ContactPrakriti Gupta

All India Institute of Medical Sciences Raipur

dratuljindal@gmail.com8224014667

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026