The participants will be given interventional drugs, Amisulpride or Granisetron. The main outcome will be to observe the effectiveness of both the drugs in preventing Post-operative nausea and vomiting for next 24hours post-operative period.

A comparison of Amisulpride with Granisetron for prevention of Post-operative Nausea and vomiting in female patients undergoing laparoscopic abdominal surgeries. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/05/086150

Enrollment

Registered

2025-05-02

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: K358- Other and unspecified acute appendicitis Health Condition 3: K450- Other specified abdominal hernia with obstruction, without gangrene Health Condition 4: N209- Urinary calculus, unspecified Health Condition 5: N859- Noninflammatory disorder of uterus, unspecified Health Condition 6: N839- Noninflammatory disorder of ovary,fallopian tube and broad ligament, unspecified

Interventions

Intervention1: Amisulpride(5mg): Amisulpride (5mg) i.v. to be given at the time of port closure, after the removal of trocars, at the end of surgery. Control Intervention1: Granisetron (1mg): Graniset

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade 1 & 2 (ASA: American Society of Anesthesiology) 2). Scheduled for laparoscopic abdominal surgeries under general anaesthesia : laproscopic cholecystectomy, laproscopic herniotomy, laproscopic appendicetomy, laproscopic hysterectomy, laproscopic tubal ligation. 3). Apfel score more than or equal to 2

Exclusion criteria

Exclusion criteria: ASA grade 3 & 4 2). Hypersenstivity to the drugs being studied. 3). A known case of Prolactin dependent tumor or pheochromocytoma or have any cardiac arrhythmia, congenital long QT syndrome. 4). Use of anti-emetic medication within 24hours prior to surgery. 5). Refusal by patient to participate.

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of amisulpride and granisetron in prevention of post-operative nausea and vomitingTimepoint: Post-operative period : Baseline (30mins), 6hours, 12 hours, 18hours and 24 hours.	—

Secondary

Measure	Time frame
Reduced incidence of nausea and vomiting. Shorter hospital stay.Timepoint: 30mins. after surgery 6hours after surgery 12 hours after surgery 18hours after surgery 24 hours after surgery	—

Countries

India

Contacts

Public ContactDr Ramesh Kumar Kharwar

Rajendra Institute Of Medical Science

dipalishio@gmail.com9620310511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026