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Comparison of incidence of sore throat in patients undergoing elective endotracheal intubation under general anesthesia after gargling with Dexmedetomidine and lidocaine, Magnesium sulphate and lidocaine, and plain lidocaine

Comparison of incidence of sore throat in patients undergoing elective endotracheal intubation under general anesthesia after gargling with dexmedetomidine - lidocaine, magnesium sulphate - lidocaine, and plain lidocaine - a randomized controlled trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/05/086144
Enrollment
177
Registered
2025-05-02
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group A: Gargling with Dexmedetomidine 1mcg/kg + 100 mg Lidocaine + 10ml 25% Dextrose with a total of 20 ml solution Intervention2: Group B: Gargling with Magnesium Sulphate 2g + 100mg

Sponsors

SRM medical college hospital and research center
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients scheduled for elective surgery requiring laryngoscopy and endotracheal intubation ASA 1 and 2 No history of head and neck surgery Surgery less than 120 minutes

Exclusion criteria

Exclusion criteria: Known allergy or contraindication to Magnesium sulphate, dexmedetomidine, to lidocaine Pre-existing sore throat or upper respiratory tract infection Bleeding during suctioning during extubation Insertion of laryngoscope more than once Pregnancy or lactation

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of Magnesium sulphate, Dexmedetomidine, and Lidocaine gargles in preventing sore throat following laryngoscopy and endotracheal intubationTimepoint: To compare the effectiveness of Magnesium sulphate, Dexmedetomidine, and Lidocaine gargles in preventing sore throat following laryngoscopy and endotracheal intubation—

Secondary

MeasureTime frame
To assess delayed recovery, changes in vitals, adverse effects of the drugs usedTimepoint: From extubation to the next 24 hours—

Countries

India

Contacts

Public ContactVenkata sai krishna praneeth koneru

SRM Medical college hospital and research center

praneeth.koneru@gmail.com9177486629

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026