EFFICACY OF INTRAVENOUS INJECTIONS OF DEXMEDETOMIDINE, LIGNOCAINE AND MAGNESIUM SULFATE IN PROVIDING STABLE INTRAOPERATIVE HAEMODYNAMICS AS A COMPONENT OF OPIOID FREE GENERAL ANAESTHESIA IN LAPRASCOPIC SURGERIES.

EVALUATING THE EFFICACY OF LIGNOCAINE AND MAGNESIUM SULFATE AS A COMPONENT OF OPIOID FREE ANAESTHESIA IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES UNDER GENERAL ANAESTHESIA. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/086068

Enrollment

128

Registered

2025-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: combination of Intravenous injection of Dexmedetomidine and Lignocaine: Patients in Group 1(DL) will receive pre and intraoperative infusions of injection Dexmedetomidine-Lignocaine com

Eligibility

Inclusion criteria

Inclusion criteria: 1.All Patients of either gender 2.Aged between 20 to 60 years 3.Belonging to American society of anaesthesiologists (ASA) physical status 1-2 4.Undergoing laparoscopic surgical procedures (Laparoscopic cholecystectomy, Laparoscopic hernia repair and Laparoscopic appendicectomy) 5.All the patients who are willing to sign written & informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients with severe - cardiovascular, respiratory, neurological, psychological, renal or hepatic disease 2. Known allergy to any of the drugs used in the study. 3. Patients on adrenergic blocking drugs 4. Patients on calcium channel blockers 5. History of alcohol, opioid & sedative drug abuse 6. Anticipated difficult airway 7. Undergoing laparoscopic gynaecological surgeries will be excluded from the study.

Design outcomes

Primary

Measure	Time frame
To determine the efficacy of the Dexmedetomidine- Lignocaine and Dexmedetomidine Magnesium sulfate drug combinations in maintaining intra-operative hemodynamic parameters within 20% of the base line values. Timepoint: 1.Laryngoscopy and Intubation 2.Creation of pneumoperitonium 3.Extubation and Emergence	—

Secondary

Measure	Time frame
1.To estimate the time to request for 1st rescue analgesic 2.Readiness to discharge from PACU as assessed by modified Aldrets score 3.Level of sedation as assessed by using Ramsay Sedation score Timepoint: Postoperatively- 0 minute, 5 minute, 10 minute, 15 minute and 20 minute for the first postoperative 20 minutes and then as and when required for the patients need till 6 hours postoperatively	—

Countries

India

Contacts

Public ContactDr H Santoshkumar Huligeri

BGS Medical College and Hospital Nagarur Bengaluru North

santoshkumarhuligeri@gmail.com9353311740

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026