Biomarkers and post operative pain in symptomatic irreversible pulpitis patients with bioceramic sealer

Correlation of Substance P and CGRP in GCF and post operative pain in symptomatic irreversible pulpitis with bioceramic sealer A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/086057

Enrollment

Registered

2025-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: BioRoot RCS: Single cone warm vertical compaction obturation will be done using F2 gutta percha points coated with BioRoot RCS Sealer. Pre operative pain and biomarker levels will be me

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male or female individuals aged 18-50 years. 2. Patients without any medication with in past 7 days. 3. Permanent Mandibular First and Second Molars diagnosed with symptomatic irreversible pulpitis. 4. The preoperative pain score more than 54mm on the 170mm Heft Parker Visual Analogue Scale.

Exclusion criteria

Exclusion criteria: 1. Patients with non-vital teeth, root fracture or cracks. 2. Subjects having teeth with periodontal probing depth of more than 3mm 3. Mandibular molars with more than 20 degree curvature, narrow calcified canals. 4. Patients who consumed analgesics 12-24 hours before the primary root canal treatment.

Design outcomes

Primary

Measure	Time frame
Reduction of post operative painTimepoint: 0hr, 24hr, 48hr, 72hr and 7th day	—

Secondary

Measure	Time frame
Reduction in biomarkers levelTimepoint: 0hr and 7th day after obturation	—

Countries

India

Contacts

Public ContactDr Sucheta Jala

Manav rachna dental college

sucheta.sds@mrei.ac.in7042643666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026