A study comparing how well different types of numbing medicines work for pain relief after lower belly surgery. We looked at plain Bupivacaine, Bupivacaine mixed with Dexmedetomidine, and Bupivacaine mixed with Clonidine, all given through an ultrasound-guided nerve block.

Comparison of efficacy of plain bupivacaine versus bupivacaine with dexmedetomidine versus bupivacaine with clonidine in Ultrasound Guided transversus abdominis Plane Block for duration of postoperative analgesia in patients undergoing lower abdominal surgeries A double blind randomized controlled study - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/086052

Enrollment

108

Registered

2025-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: Plain bupivacaine: 0.25% plain bupivacaine TAP block bilateral given post surgery Control Intervention1: Bupivacaine with dexmeditomidine: 0.25% of bupivacaine plus 0.5 micrograms/kg de

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA Grade I or II. 2.Patients undergoing lower abdominal surgeries. 3.Patients undergoing surgery under spinal

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Primary objective: Comparison of efficacy of plain Bupivacaine versus Bupivacaine with Dexmedetomidine versus Bupivacaine with Clonidine in Ultrasound Guided Transversus Abdominis Plane Block for duration of postoperative analgesia in patients undergoing lower abdominal surgeries.Timepoint: Before giving block and after giving block 0 hour, 2hour, 4th hour, 6th hour 8 th hour, 12 th hour,16 th hour, 20th hour and 24 th hour	—

Measure

Time frame

Primary objective: Comparison of efficacy of plain Bupivacaine versus Bupivacaine with Dexmedetomidine versus Bupivacaine with Clonidine in Ultrasound Guided Transversus Abdominis Plane Block for duration of postoperative analgesia in patients undergoing lower abdominal surgeries.Timepoint: Before giving block and after giving block 0 hour, 2hour, 4th hour, 6th hour 8 th hour, 12 th hour,16 th hour, 20th hour and 24 th hour

—

Secondary

Measure	Time frame
1. Side effects of the administered drugs. 2. Sedation (using modified Ramsay sedation score)Timepoint: 24 hrs	—

Countries

India

Contacts

Public ContactDr Rampal Singh

AIIMS RAIPUR

drrampalsingh@aiimsraipur.edu.in9027335921

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026