Health Condition 1: -
Conditions
Interventions
Intervention1: Chemotherapy: 6 cycles of weekly Paclitaxel/Carboplatin
Control Intervention1: Standard chemoradiotherapy: 45GY/25# with 6 cycles concurrent cisplatin followed by 4 fraction 7GY intra c
Sponsors
AIIMS RISHIKESH
Eligibility
Inclusion criteria
Inclusion criteria: Histologically proven Squamous/Adeno/Adeno-squamous Carcinoma Cervix Histologically confirmed FIGO (2018) stage IB3, IIA2, IIB, IIIA, IIIB, IIIC1, IVA cancers Adequate renal and liver function Normal blood parameters ECOG 0-2 No prior pelvic RT
Exclusion criteria
Exclusion criteria: IIIC2 and IVB Disease. Post operative cases Recurrent carcinoma cervix Pregnancy or lactation Patients unwilling to receive NACT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aim To assess and compare the response rates and acute toxicity rates in locally advanced carcinoma cervix patients receiving NACT followed by CTRT Vs CTRT alone Primary Objective To assess and compare locoregional treatment response rate in both treatment groups at 3 months post treatment completion Timepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess & compare acute toxicity in both treatment groups To assess treatment breaks & rates of hospitalisation Timepoint: weekly during treatment | — |
Countries
India
Contacts
Public ContactDeepa M Joseph
Department of Radiation Oncology, AIIMS Rishikesh
Outcome results
None listed