Comparison between Nitroglycerine and Lignocaine spray for reducing blood pressure and heart rate response during laryngoscopy and intubation in patients undergoing elective surgeries

Comparison between Nitroglycerine and Lignocaine spray for attenuation of pressor response during laryngoscopy and endotracheal intubation in patients undergoing elective surgery under general anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/085989

Enrollment

Registered

2025-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Attenuation of pressor response to endotracheal intubation: Patients posted for elective surgery under general anaesthesia will be considered for the study. The patients will be randoml

Eligibility

Inclusion criteria

Inclusion criteria: Patients of American Society of Anesthesiologists (ASA) physical status grade I and II undergoing elective surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: Patient refusal ,patients with ischemic /Valvular heart disease , Renal and liver dysfunction and patients with known hypersensitivity to Lignocaine and Nitroglycerine are excluded.

Design outcomes

Primary

Measure	Time frame
To compare the systolic blood pressure variation between the two groups at baseline , at the time of intubation and till 15 mins post intubation.Timepoint: To compare the systolic blood pressure variation between the two groups at baseline , at the time of intubation and till 15 mins post intubation.	—

Secondary

Measure	Time frame
To compare the heart rate , diastolic blood pressure & mean arterial pressure between the two groups at baseline , at the time of intubation andtill 15 mins post intubation.Timepoint: To compare the heart rate , diastolic blood pressure & mean arterial pressure between the two groups at baseline , at the time of intubation & till 15 mins post intubation.	—

Countries

India

Contacts

Public ContactDr Kavin Prasad M

Narayana Hrudayalaya ,Narayana Health City

indumathi.t.dr01@narayanahealth.org9538533850

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026