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Injection of Hyaluronidase after Third Molar Surgery

Efficacy of Submucosal Injection of Hyaluronidase after Mandibular Third Molar Surgery : A Randomized Controlled Trial - NIL

Status
Recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085988
Enrollment
60
Registered
2025-04-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: M263- Anomalies of tooth position of fully erupted tooth or teeth

Interventions

Intervention1: Injection Hyaluronidase 1500IU: Submucosal Injection of Hyaluronidase (HUD)1500 IU/ml given after Surgical Removal of Impacted Mandibular Third Molars.A total of 1.0 mL of will be inje

Sponsors

Dr Disha Parbat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) I: A normal healthy patient. 2. Patients with impacted mandibular third molars requiring surgical extraction under local anesthesia. 3. Patients with Pederson s difficulty index score 5-6 (Moderately Difficult). 4. Compliance with the study following voluntary participation.

Exclusion criteria

Exclusion criteria: 1. Impacted third molars with associated pathology & acute infection. 2. Tobacco chewers and smokers. 3. Medically compromised patients. 4. Patients who have a known allergy to a local anesthetic solution. 5. Pregnant and lactating females or patients on oral contraceptives.

Design outcomes

Primary

MeasureTime frame
Visual Analog Pain Scale: 1-10. Edema. Patient Centred Outcome Questionnaire. Timepoint: 1st, 3rd, and 7th day.

Secondary

MeasureTime frame
Age, Gender Trismus Post-operative pain on 1st, 3rd , 7th day. Timepoint: Visual Analog Pain Scale: 1-10. Age, Gender

Countries

India

Contacts

Public ContactDr Sushant Kumar Soni

Chhattisgarh Dental College and Research Institute.

drsushant.soni.21@gmail.com9826159917

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026