Skip to content

Studying how changes in genes of two beneficial enzymes (SOD2 and CAT) might be linked to gum disease a comparison between those with and without the condition.

Evaluation of the association of SOD2 and CAT gene polymorphisms in patients with periodontitis- a case- control study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/04/085968
Enrollment
172
Registered
2025-04-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Nil: Nil

Sponsors

SAKTHI KAMALA VEGASHINI K
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients of age 30 to 60 are to be recruited for the study. 2. Ethnic South Indian subjects 3. Control group to include subjects with no signs of periodontal disease and probing sulcus depth of less than or equal to 3mm with no evidence of clinical attachment loss. 4. Test group to include patients with Probing Pocket Depth of more than or equal to 5mm and/or Clinical Attachment Loss of more than or equal to 3mm in greater than 30 percentage of sites with periodontitis. (Stage II/III Periodontitis)

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA: 1. Patients with any inflammatory systemic conditions such as diabetes mellitus, rheumatoid arthritis, etc. 2. Patients with immunodeficiency disorders. 3. Patients with local modifiers like food impaction, factitious habits and bruxism. 4. Patients who smoke. 5. Use of orthodontic and prosthetic appliances. 6.Patients who had taken systemic antibiotic, anti-inflammatory, hormonal or other assisted drug therapy in the last 6 months or prior to the study.

Design outcomes

Primary

MeasureTime frame
compare the association of rs1799725 of SOD2 and rs7943316 of CAT gene polymorphism in patients with and without periodontitis and susceptibility of developing periodontitisTimepoint: Baseline

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDR SANGEETHA SUBRAMANIAN
sangeetha_doc@yahoo.com9884563217

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026