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To know the effect of two oral drugs clonidine and melatonin in patients posted for surgeries in the nasal cavity.

Effect of Oral Melatonin and Oral Clonidine Premedication on Hemodynamic Response To Laryngoscopy and Intubation and Intraoperative Period in Patients Posted For FESS - A double blinded randomised prospective comparative study - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085921
Enrollment
30
Registered
2025-04-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J339- Nasal polyp, unspecified

Interventions

Intervention1: To use oral melatonin in premedication to attenuate the response to intubation in patients posted for FESS surgery: Direct laryngoscopy and intubation act as a powerful noxious stimu

Sponsors

Department of Anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and ASA II patients Patients posted for elective FESS procedure under General Anaesthesia

Exclusion criteria

Exclusion criteria: Anticipated difficult airway BMI more than 30 pregnancy and lactating mothers

Design outcomes

Primary

MeasureTime frame
Attenuation of hemodynamic response during intubationTimepoint: Attenuation of hemodynamic response during intubation at baseline 3minutes 5minutes 15minutes and intraoperatively for every 20 minutes till extubation—

Secondary

MeasureTime frame
To avoid INTRAOPERATIVE hypertension during the procedure Analgesic efficacy during the postoperative period.Timepoint: Intraoperative for every 15minutes during the first hour of the procedure and then every 30 mins till extubation Postoperatively in immediate postoperative period , 4th. , 6th , 12th , 24 hours—

Countries

India

Contacts

Public ContactKARPAGAM G

Velammal medical college hospital and research institute , madurai

gkav2192@gmail.com7397127446

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026