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ANTIMICROBIAL EFFICACY OF BACTERIOCIN (NISIN), PROBIOTIC AND CALCIUM HYDROXIDE AS INTRACANAL MEDICAMENTS

COMPARATIVE EVALUATION OF ANTIMICROBIAL EFFICACY OF BACTERIOCIN (NISIN), PROBIOTIC (LACTOBACILLUS & BIFIDOBACTERIUM) AND CALCIUM HYDROXIDE AS INTRACANAL MEDICAMENTS BY USING REAL TIME POLYMERASE CHAIN REACTION A RANDOMISED CLINICAL TRIAL - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085920
Enrollment
36
Registered
2025-04-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K047- Periapical abscess without sinus Health Condition 2: K045- Chronic apical periodontitis Health Condition 3: K046- Periapical abscess with sinus Health Condition 4: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Probiotic containing Lactobacillus and Bifidobacterium species: Commercially available probiotic capsule containing Lactobacillus and Bifidobacterium species is placed in to the root ca

Sponsors

POOJA P
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with age group of 17-45 years of either gender presenting non vital tooth with symptomatic apical periodontitis of maxillary anteriors. Root canal re-treatment cases with periapical pathology. Patients with no systemic disease. Periodontally healthy individuals. Patients with good oral hygiene. Patients willing for voluntary participation & have signed informed Consent.

Exclusion criteria

Exclusion criteria: Tooth with calcified pulp chambers. Patients under antibiotic medications. Grossly decayed tooth. Root resorption. Root caries. Fractures. Existence of periodontal pocket greater than 4mm. Patient with contributory medical history. Pregnant women.

Design outcomes

Primary

MeasureTime frame
REDUCTION IN INTRACANAL BACTERIAL LOAD AFTER 7 DAYSTimepoint: 1 AND 7 DAYS—

Secondary

MeasureTime frame
REDUCTION IN POSTOPERATIVE PAINTimepoint: 48 HOURS—

Countries

India

Contacts

Public ContactPOOJA P

TAMILNADU GOVERNMENT DENTAL COLLEGE AND HOSPITAL

isharamah@gmail.com9094314448

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026