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Comparing Different Treatments to Heal Bone Loss Caused by Severe Gum Disease Using Laser Therapy, Natural Proteins, and Growth Factors

CLINICAL AND RADIOGRAPHICAL EVALUATION OF PHOTOBIOMODULATION WITH ENAMEL MATRIX DERIVATIVE (EMD) AND CONCENTRATED GROWTH FACTOR (CGF) IN THE MANAGEMENT OF INTRABONY PERIODONTAL DEFECTS IN STAGE III or IV PERIODONTITIS PATIENTS: A MULTI ARM PARALLEL GROUP RANDOMIZED TRIAL - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085914
Enrollment
55
Registered
2025-04-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: EVALUATION OF PHOTOBIOMODULATION WITH ENAMEL MATRIX DERIVATIVE (EMD) AND CONCENTRATED GROWTH FACTOR (CGF) IN THE MANAGEMENT OF INTRABONY PERIODONTAL DEFECTS: CLINICAL AND RADIOGRAPHICAL

Sponsors

SIVSRI ROSHAN G M
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with an age range of 18 to 60. Patients with probing pocket depth greater than or equal to 6 mm and clinical attachment loss of greater than or equal to 3 mm. Patients with 2 walled or 3 walled intrabony defects, with a defect depth of greater than or equal to 3 mm. Full-mouth plaque score (FMPS) less than 20 percent after phase I therapy Full-mouth bleeding score(FMBS) less than 20 percent after phase I therapy Systemically healthy patients; with no disease that will have a bearing on the outcome of the surgical intervention

Exclusion criteria

Exclusion criteria: Patients diagnosed with mal-alignment at the defect site Patients with systemic disease or drugs that contraindicate periodontal surgery. Patients with a history of smoking and pan chewing. Sites with advanced furcation involvement. Pregnant and lactating women

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the following clinical outcome measures: 1.Clinical Attachment Level gain (CAL) between groups. 2.Probing Pocket Depth (PPD) reduction between groups. 3.Radiographic bone fill between the groupsTimepoint: Baseline 1 month 3 month 6 month 12 month—

Secondary

MeasureTime frame
To evaluate and compare the position of the gingival crest between the groups.Timepoint: Baseline 1 month 3 month 6 month 12 month—

Countries

India

Contacts

Public ContactDHAYANAND JOHN VICTOR

SRM Dental College Ramapuram

dr.djvictor@gmail.com9841009952

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026