A comparative study in acheiv ing rapid onset intubation with different types of muscle relaxant(Rocuronium) with or without adjuvant(Magnesium sulphate)

A comparative study of Rocuronium priming with Magnesium Sulfate pre-treatment in Achieving Rapid Onset of Intubating conditions-A Randomised Controlled Trail. - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/085837

Enrollment

Registered

2025-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified

Interventions

Intervention1: rocuronium with magnesium sulphate: Patient will be given magnesium sulphate( 50mg/kg over 10 minutes) 30 mins before intubating the patient using rocuronium( 0.45mg/kg ) as muscle re

Eligibility

Inclusion criteria

Inclusion criteria: 1 ASA grade 1 and 2 patients. 2 Age 18-70 years. 3 Mallampatti class 1 and 2.

Exclusion criteria

Exclusion criteria: 1. Refusal of consent. 2. Known or anticipated difficult airway. 3. Pregnant patients 4. Patients with BMI of 30 or more. 5. Patients with significant hepatic,renal,metabolic and neuro- muscular disorders. 6. Patient receiving drugs like aminoglycosides, polymyxin A and B, colistin, clindamycin, lincomycin that influence neuromuscular functions.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of magnesium pretreatment on rocuronium priming to reduce the onset time of intubation.Timepoint: 30 minutes	—

Secondary

Measure	Time frame
To assess the intubating conditions using Cooper s scoring system. To observe the duration of rocuronium induced neuromuscular block after pretreatment with magnesium sulfate. To evaluate the adverse effectsTimepoint: 60 MINS	—

Countries

India

Contacts

Public ContactDr Anand

chettinad hospital and research insitute

dranandmurugan@gmail.com9444486183

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026