treatment of bone loss with receding gums using soft tissue graft compared with autologous heat compressed platelet-rich- fibrin membrane

Evaluation of the efficacy of Guided tissue regeneration using autologous heat compressed platelet-rich-fibrin membrane compared to subepithelial connective tissue graft in the management of RT1 marginal tissue recession : A Randomized controlled study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/085830

Enrollment

Registered

2025-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Coronally Advanced Flap with Subepithelial Connective Tissue Graft: The Zucchelli and De Sanctis 2007 coronally advanced flap procedure is used to treat isolated gingival recession. R

Eligibility

Inclusion criteria

Inclusion criteria: 1.localised gingival recession of at least 2mm in depth with minimum width of attached gingiva as more than 3mm apical to recession 2.presence of identifiable buccal cemento-enamel-junction without any carious, non carious, cervical lesion or restoration 3.in good general health(ASA 1) 4.palatal mucosal thickness more than 2.5 mm as assesses by trans gingival probing which serves as donor site

Exclusion criteria

Exclusion criteria: 1.pregnancy and lactating women 2.teeth with evidence of a pulpal pathology and a non-vital tooth 3.teeth that had periodontal surgical procedure for root coverage in the last 2 years 4.subjects who are active smokers at the time of screening

Design outcomes

Primary

Measure	Time frame
1. Recession depth reduction [Time Frame:6 months] -Measured from the reference stent margin to the most apical extension of the gingival margin; will be measured in mm 2.Mean root coverage (MRC), calculated as [(Baseline RD) (6 months RD)/Baseline RD] 100%. 3.complete root coverage (CRC), calculated as the percentage treated site with 100% coverage Timepoint: 0-6 months	—

Secondary

Measure	Time frame
1.Pain assessment at the donor site [ Time Frame: 7 days] -Visual Analogue Scale 2.Number of analgesic pills consumed per day [ Time Frame:1- 7 days] -counting number of analgesic pills per day 3.Height of keratinized tissue width [ Time Frame: baseline and at 6 months] -measured form the mid-buccal aspect of the gingival margin to the mucogingival line 4.Relative attachment level [ Time Frame: baseline-3-6 months] -Measured from the stent margin to the bottom of the periodontal pocket to the nearest mm. 5.Root Coverage Esthetic score. [Baseline- 6 months]Timepoint: 0-6 months	—

Measure

Time frame

1.Pain assessment at the donor site [ Time Frame: 7 days] -Visual Analogue Scale 2.Number of analgesic pills consumed per day [ Time Frame:1- 7 days] -counting number of analgesic pills per day 3.Height of keratinized tissue width [ Time Frame: baseline and at 6 months] -measured form the mid-buccal aspect of the gingival margin to the mucogingival line 4.Relative attachment level [ Time Frame: baseline-3-6 months] -Measured from the stent margin to the bottom of the periodontal pocket to the nearest mm. 5.Root Coverage Esthetic score. [Baseline- 6 months]Timepoint: 0-6 months

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Countries

India

Contacts

Public ContactDr Surabhi

Government dental college and research institute

periosmitha@gmail.com9449630572

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026